منابع مشابه
Beyond viral suppression of HIV – the new quality of life frontier
BACKGROUND In 2016, the World Health Organization (WHO) adopted a new Global Health Sector Strategy on HIV for 2016-2021. It establishes 15 ambitious targets, including the '90-90-90' target calling on health systems to reduce under-diagnosis of HIV, treat a greater number of those diagnosed, and ensure that those being treated achieve viral suppression. DISCUSSION The WHO strategy calls for ...
متن کاملSuppression of viral infectivity through lethal defection.
RNA viruses replicate with a very high error rate and give rise to heterogeneous, highly plastic populations able to adapt very rapidly to changing environments. Viral diseases are thus difficult to control because of the appearance of drug-resistant mutants, and it becomes essential to seek mechanisms able to force the extinction of the quasispecies before adaptation emerges. An alternative to...
متن کامل[Innate immune responses against viral infection and its suppression by viral proteins].
Retinoic acid-inducible gene-I(RIG-I) is a cytoplasmic RNA helicase and a viral RNA sensor. RIG-I recognizes 5' triphosphate double-stranded RNA (dsRNA) and activates the IPS-1 adaptor molecule. The association of IPS-1 with RIG-I causes the formation of the prion-like structure of IPS-1. This structure is essential for activation of the signaling required for the induction of type I interferon...
متن کاملDisturbance Suppression beyond Nyquist Frequency in Hard Disk Drives
In conventional hard disk drives, a control system compensates for vibration in which the frequency is higher than the Nyquist frequency by using a multi-rate filter that decreases the gain above the Nyquist frequency. However, such a control system can only avoid instability and cannot suppress disturbances above the Nyquist frequency. In response to this problem, a control system design metho...
متن کاملViral DNAemia and Immune Suppression in Pediatric Sepsis.
OBJECTIVES Demonstrate that DNA viremia is common in pediatric sepsis and quantitate its associations with host immune function and secondary infection risk. DESIGN Retrospective analysis of a prospective cohort study. PATIENTS Seventy-three children admitted with sepsis-induced organ failure. INTERVENTIONS None. MEASUREMENTS AND MAIN RESULTS This study was performed as an ancillary inv...
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ژورنال
عنوان ژورنال: Open Forum Infectious Diseases
سال: 2021
ISSN: 2328-8957
DOI: 10.1093/ofid/ofab044